Microbial production of plant specialized metabolites

Specialized Bioactive Microbial Metabolites: From Gene to Product

1Department of Biotechnology and Life Sciences, University of Insubria andThe Protein Factory, Interuniversity Centre Politecnico di Milano, ICRM CNR Milano and University of Insubria, Varese, Italy 2Fundación MEDINA, Health Sciences Technology Park, Granada, Spain 3Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, Ukraine 4Department of Molecular Microbiology a...

Microbial Production of Plant Hormones

Microbial Secondary Metabolites Production and Strain Improvement

Microbial secondary metabolites are compounds produced mainly by actinomycetes and fungi, usually late in the growth cycle (idiophase). Although antibiotics are the best known secondary metabolites (SM), there are others with an enormous range of other biological activities mainly in fields like: pharmaceutical and cosmetics, food, agriculture and farming. These include compounds with anti-infl...

Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research

Plants produce a variety of secondary metabolites that possess strong physiological activities. Unfortunately, however, their production can suffer from a variety of serious problems, including low levels of productivity and heterogeneous quality, as well as difficulty in raw material supply. In contrast, microorganisms can be used to produce their primary and some of their secondary metabolite...

The biosynthesis of plant alkaloids and nitrogenous microbial metabolites.

The biosynthesis of plant alkaloids and related nitrogenous microbial secondary metabolites is reviewed. This involves discussion of the outcome of studies with isotopic labels and of genetic and enzymic experiments. The review follows on from a similar, earlier account [Nat. Prod. Rep., 2001, 18, 50-65], covers the literature for the calendar years 1999 and 2000, and contains 143 references.